Effects of Bacillus cereus PAS38 on Growth Performance and Immune Function of Broilers

doi:10.7668/hbnxb.20190222

Abstract

Abstract: The paper was designed to investigate the effects of Bacillus cereus PAS38 on growth performance and immune function of broilers. A total of 80 7-day-old Arbor Acres(AA) broilers were randomly divided into 2 groups with 4 replicates in each group and 10 broilers in per replicate. The control group was fed the basal diet, and the treatment group was fed the basal diet supplemented with 0.05% the additive of Bacillus cereus PAS38. The experiment was conducted for 35 d. The results showed: The body weight and weight gain of broilers in the treatment group were higher than those of the control group, but the difference was significant at 28 d(P<0.05). Amylase and protease activities in the ileum and jejunum of the treatment group were higher than those of the control group(P<0.05 or P<0.01). The index of thymus and bursa fabricii in the treatment group were higher than those of the control group at 28 d and 42 d(P<0.05 or P<0.01), and the bursa fabricii index was significant at 42 d(P<0.05). The serum immunoglobulin content of the treatment group was higher than that of the control group(P<0.05 or P<0.01). The serum IL-2 and IFN-γ levels of the treatment group were higher than those of the control group(P>0.05) and IL-4 content was lower than that of the control group at 42 d(P>0.05). The mRNA expression levels of IL-2, IFN-γ, GBP1 and IRF1 in the thymus and the bursa fabricii of the treatment group were higher than those of the control group, and the IL-10 mRNA transcription level was lower than that of the control group; IL-4 mRNA transcription level of the treatment group was significantly higher than that of the control group in the thymus(P<0.05), but it was significantly lower(P<0.05) and extremely significant(P<0.01) in the bursa fabricii. It is concluded that Bacillus cereus PAS38 could promote the growth performance of broilers, increase the activities of intestinal digestive enzymes, stimulate the development of immune organs, and improve the non-specific immunity and cellular immunity by regulating the expression of mRNA of immune-related genes.

Key words: Broiler, Bacillus cereus, Growth performance, Intestinal digestive enzyme activity, Immune function

CLC Number:

S432.4

ZHANG Jiao, WANG Zhenhua, PAN Kangcheng, NI Xueqin, LI Jiajun, LI Jianzhen, GU Xiaoxiao. Effects of Bacillus cereus PAS38 on Growth Performance and Immune Function of Broilers[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2019, 34(S1): 340-345. doi: 10.7668/hbnxb.20190222.

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