Association between the G901A PolymoRphism of HIF-1α Gene and Adaptation to High-altitude Hypoxia

doi:10.7668/hbnxb.2013.06.019

Abstract

Abstract: To investigate the association between the G 901 A polymorphism of HIF-1αgene and adaptation to high-altitude hypoxia, the G901 A of HIF-1αgene were genotyped using high resolution melting analysis in 112 un-related healthy Tibetan sheep ( Higher than 3 000 m altitude ) and 117 low altitude sheep ( Lower than 500 m alti-tude).Our results showed all the genotypes of the loci were significantly different between the two groups ( P <0.01).The frequencies of genotypes G/G,G/A and A/A at HIF-1α901 locus in Tibetan sheep were 41.07%, 46.43% and 12.5%,respectively in low altitude sheep, they were 66.67%,27.35%and 5.98%.Whilst in Tibet-an sheep allele frequencies of G and A were 64.29%and 35.71%,respectively but they were 81.34%and 19.66%respectively in the low altitude sheep (P<0.01).Our results indicate that the polymorphism of genotype in the G901 A of HIF-1αgene were associated with adaptation to high-altitude hypoxia.The sheep with AA genotype may be more conducive to hypoxia.

Key words: Tibetan sheep, HIF-1&alpha, gene, Adaptation to high-altitude hypoxia, Single nucleotide polymoRphism

CLC Number:

S826

YANG Min, SHI Zhao-guo, HAN Ji-long, YUE Yao-jing, GUO Ting-ting, GUO Jian, LIU Jian-bin, SUN Xiao-ping, WANG Chao-feng, YANG Bo-hui. Association between the G901A PolymoRphism of HIF-1α Gene and Adaptation to High-altitude Hypoxia[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2013, 28(6): 111-114. doi: 10.7668/hbnxb.2013.06.019.

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