Differential Expression and Biological Functions of Related Genes to Porcine Malignant Hyperthermia Syndrome

doi:10.7668/hbnxb.2014.05.010

Abstract

Abstract: To detect gene expression changes after suffering from porcine malignant hyperthermia syndrome(pMHS)and analyze the biological significance of differential expression genes in the process of disease infection.Three pigs were used in this study as cases and controls,respectively.Gene chips was conducted to investigate gene expression difference between two groups.Gene ontology and pathway analysis were applied to determine the roles of these differentially expressed genes in pMHS by NCBI and NETWORK.138 genes were identified in MHS pigs,including 30 up-regulated and 108 down-regulated genes,comparison with the control group.These genes were confirmed associated mainly with the regulation of immune defense,biochemistry,organic stress,etc,and involved in 26 signal pathways,of which SLA-DMA mediated immune defense pathway plays an important role in pMHS.The expression changes of stefinA1,APOD,SLA-DMA genes result in immune dysfunction,which was crucial in the pathological process of pMHS.

Key words: Pig, Malignant hyperthermia syndrome, Gene expression, Bioinformatics

CLC Number:

Q78
5828

FANG Xiao-min, TU Feng, REN Shou-wen, WANG Xue-min, LI Bi-xia, FU Yan-feng, ZHAO Wei-min, ZHAO Fang. Differential Expression and Biological Functions of Related Genes to Porcine Malignant Hyperthermia Syndrome[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2014, 29(5): 54-58. doi: 10.7668/hbnxb.2014.05.010.

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