[1] Michel Goedert.A century of Alzheimer′s disease[J].Science,2006,314:777 -781.
[2] Mark A,Findeis.The role of amyloid β peptide 42 inAlzheimer' s disease [J].Pharmacology & Therapeutics,2007,116:266 -286.
[3] Schenk D,Barbour R,DunnW,et al.Immunization with amyloid-β attenuates Alzheimer′s disease -like pathology in thePDAPP mouse [J].Nature,l999,400 :l73 -177.
[4] Bard F,Cannon C,Barbour R,et al.Peripherally administeredantibodies against amyloid beta peptide enter the central nervoussystem and reduce pathology in a mouse mode ofAlzheimer disease [J].NatMed,2000,6:916 -920.
[5] Schenk E.Nerve inflammation halts trial for Alzheimersp drug[J].Nature,2002,415:462.
[6] Alon M,Ruth M,Victor Z,et al.Immune hyporesponsivenessto amyloid β peptide in amy loid precursor protein transgenicmice:implications for the pathogenesis and treatment ofAlzheimers disease [J].Proc Natl Acad Sci USA,2001,98(18):10273 -10278.
[7] Mason HS,Lam DMK,Arntzen CJ,et al.Expression of hepatitisB surface antigen in transgenic plants [J].Proc Natl AcadSci USA,1992,89:11745 -11749.
[8] D.E.Webster,M.C.Thomas,Z Huang,et al.The developmentof a plant -based vaccine for measles[J].Vaccine ,2005,23 :1859-1865.
[9] Henry Daniell.Expression of the nNative cholera toxin B subunitgene and assembly as functional oligomers in transgenictobacco chloroplasts[J].J Mol Biol,2001,311:1001 -1009.
[10] Kim H S,Euym J W.Expression of human amy loid-β peptidein transgenic potato[J].Plant Sci,2003,165 :1445 -1451.
[11] Jung Won Youm,Hee Kim,Jee Hye Lo Han,et al.Transgenicpotato expressing Aβ reduce Aβ burden in Alzheimer′sdisease mouse model[J].FEBS Letters,2005,579:6737 -6744.
[12] 王关林,方宏筠.植物基因工程(第2 版)[M].北京:科学出版社,2002,795 -798.
[13] 秦宏伟.转基因植物生物反应器中存在的问题及解决途径[J].生命的化学,2007,27(2):156 -158.
[14] 郝 林,曹 军.CaMV35S 双启动子显著提高转基因在拟南芥中表达水平的研究[J].植物生理学报,2000 ,36(6):517 -519. |