Study on Influenza Receptors in Respiratory and Intestine Tract of Cherry Valley Duck

doi:10.7668/hbnxb.2015.S1.067

Abstract

Abstract: To study the type and distribution of influenza virus receptors in Cherry valley ducks,SAα2,3-Gal and SAα2,6-Gal influenza viruses receptors in respiratory tract and alimentary tract of Cherry valley ducks were investigated by affinity immunohistochemical method in this study.Results showed that there were abundant SAα2,6-Gal and SAα2,3-Gal in the trachea,bronchus,alveolar epithelium cell of Cherry valley duck.But the expression of the two receptors was different in the rectum,SAα2,3-Gal receptor in the rectum showed a high density distribution,while SAα2,6-Gal receptor was slightly lower.In Cherry valley ducks,SAα2,3-Gal and SAα2,6-Gal receptor both could be expressed,these showed that Cherry valley duck was susceptible not only to avian influenza virus but also to human influenza virus.

Key words: Cherry valley ducks, Influenza A virus, Sialic acid receptors, Affinity immunohistochemistry

CLC Number:

S834

ZHANG Chuan-mei, LUO Yao-yao, YANG Hai-yan, WANG Jian-lin, SHAN Hu. Study on Influenza Receptors in Respiratory and Intestine Tract of Cherry Valley Duck[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2015, 30(S1): 372-375. doi: 10.7668/hbnxb.2015.S1.067.

/ / Recommend / Download Citations

URL: http://www.hbnxb.net/EN/10.7668/hbnxb.2015.S1.067

http://www.hbnxb.net/EN/Y2015/V30/IS1/372

References

[1] 甘孟侯.禽流感[M].2版.北京:中国农业出版社,2002.
[2] 韦平,秦爱建.重要动物病毒分子生物学[M].北京:科学出版社,2008.
[3] Enserink M,Kaiser J.Avian flu finds new mammal hosts[J].Science,2004;305:1385
[4] Whittle J R,Zhang R,Khurana S,et al.Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(34):14216-14221.
[5] Glaser L,Stevens J,Zamarin D,et al.A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity[J].Journal of Virology,2005,79(17):11533-11536.
[6] Gerhard W,Yewdell J,Frankel M E,et al.Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies[J].Nature,1981,290(588):713-717.
[7] Rello J,Pop-Vicas A.Clinical review:primary influenza viral pneumonia[J].Critical Care,2009,13(6):235.
[8] Skehel J J,Wiley D C.Receptor binding and membrane fusion in virus entry:the influenza hemagglutinin[J].Annual Review of Biochemistry,2000,69(1):531-569.
[9] 流感病毒的受体结合特性与跨种传播[J].生命世界,2014,08:16.
[10] Connor R J,Kawaoka Y,Webster R G,et al.Receptor specificity in human,avian,and equine H2 and H3 influenza virus isolates[J].Virology,1994,205(1):17-23.
[11] Webster R G,Bean W J,Gorman O T,et al.Evolution and ecology of influenza A viruses[J].Microbiological Reviews,1992,56(1):152-179.
[12] 张增峰.人呼吸道甲型流感病毒受体的分布和感染H5N1流感病毒的病理变化[D].汕头:汕头大学,2007.
[13] 许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231.
[14] Sturm-Ramirez K M,Hulse-Post D J,Govorkova E A,et al.Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia[J].Journal of Virology,2005,79(17):11269-11279.
[15] Gambaryan A,Webster R,Matrosovich M.Differences between influenza virus receptors on target cells of duck and chicken[J].Archives of Virology,2002,147(6):1197-1208.
[16] 宁章勇,刘雪梅,罗敏意,等.流感病毒受体在三种动物气管和肺脏分布的组织化学检测[J].中国动物检疫,2009,04(4):44-47.
[17] 张增峰,樊晓晖,罗殿中,等.鸭呼吸道和消化道流感病毒SA受体的分布特征[J].内科,2011,05(5):393-396.

Please choose a citation manager

Content to export