Abstract:
A total of 20 foot-and mouth disease virus (FMDV) serotype O was obtained from C}nbank and was divided into 12 encoding sequences (Lab,V P4,VP2,V P3,V PI,2A,2B,2 C, 3A,3B,3C and 3D).After analng the didference among them by analysis of variance,at the nucleotide level,the relative mutation rates of these 12 encoding se-quences were no difference(P>0.05),however,at the amino acid level,those relative mutation rates were different(P<0. 01).And the analysis of Duncan method indicated that the relative mutation rate of 3A protein is the highest. Compari-son with VP4,3CPro,3DPol,2A,2C,the relative mutation rates of VP2 and LPro were different than them( P<0. 05).Inaddition,the relative mutation rates of VP4,3CPro,3DPol,2A,2C were。different. The proposed results strongly suggestedthat serotype O FMDV RNA transcription and the pressure of immunity failed to play an important role in driving FMDV genome evolution. An evolutionary pressure is related to functional conservation.
Key words:
Foot-and mouth disease virus,
Relative mutation rate,
Analysis of variance,
Duncan method
CLC Number:
ZHOU Jian-hua, CONG Guo-zheng, CHANG Hui-yun. The Analysis of Products Mutation Rate of Encoding Sequences and Their Products in Serotype O Foot-and-Mouth Disease Virus[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2009, 24(1): 60-63. doi: 10.7668/hbnxb.2009.01.014.