免疫球蛋白样和纤维连接蛋白Ⅲ型域含蛋白IGFN1参与骨骼肌应激损伤调控的研究进展

doi:10.7668/hbnxb.201751759

摘要/Abstract

摘要： IGFN1基因可在骨骼肌中特异性表达，并呈现出免疫球蛋白Ⅰ和纤维连接蛋白Ⅲ组合的肌小节蛋白的结构域特征。其作用主要是参与蛋白翻译、肌细胞分化、骨骼肌收缩和细胞骨架稳定等。本研究主要对IGFN1基因的结构特点、在动物体内的基因表达调控、参与的信号转导途径，以及动物氧化应激反应与IGFN1表达之间的关系等方面的相关研究进展进行综述，以期为骨骼肌纤维类型转换相关机制的研究提供资料，也为氧化应激条件下修复肌肉损伤及改善猪肉品质的深入研究提供新思路。

关键词: IGFN1, 骨骼肌, 应激, MAPK信号通路, 肌肉生长抑制素

Abstract: IGFN1 is a complex locus that codes for multiple splicing variants of Immunoglobulin-and Fibronectin-like domain containing proteins predominantly expressed in skeletal muscle. IGFN1 mainly plays a role in protein translation, muscle cell differentiation, skeletal muscle contraction and cytoskeletal stability. This paper mainly reviews the research progress of structural features, expression in animals, regulation of the gene expression, signaling pathway of IGFN1 and the relationship between oxidative stress and IGFN1 expression in recent years, so as to provide information for the study of the mechanism of skeletal muscle fiber type conversion. Furthermore, this project will provide the scientific basis for stress damage repair, and is significant for improving the quality of pork.

Key words: IGFN1, Skeletal muscle, Stress, MAPK signaling pathway, Myostatin

中图分类号:

Q342

郝月, 辛海瑞, 张闯, 顾宪红. 免疫球蛋白样和纤维连接蛋白Ⅲ型域含蛋白IGFN1参与骨骼肌应激损伤调控的研究进展[J]. 华北农学报, 2019, 34(S1): 380-385. doi: 10.7668/hbnxb.201751759.

HAO Yue, XIN Hairui, ZHANG Chuang, GU Xianhong. Advances in Research of Immunoglobulin-Like and Fibronectin Type Ⅲ Domain Containing 1 Involved in the Regulation of Skeletal Muscle Stress Damage[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2019, 34(S1): 380-385. doi: 10.7668/hbnxb.201751759.

http://www.hbnxb.net/CN/Y2019/V34/IS1/380

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