华北农学报 ›› 2001, Vol. 16 ›› Issue (2): 127-131. doi: 10.3321/j.issn:1000-7091.2001.02.025

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ETEC多价定居因子对仔猪大肠杆菌病的预防试验

李学伍, 张改平, 阎玉河, 邓瑞广, 杨艳艳, 王爱萍, 李青梅   

  1. 河南省农业科学院生物技术研究所, 河南郑州 450002
  • 收稿日期:2000-01-24 出版日期:2001-06-28
  • 作者简介:李学伍(1964- ),男,副研究员,主要从事畜禽疾病的防治研究工作。
  • 基金资助:
    河南省九五科技攻关项目(961040202)

Protection Against Piglets Colibacillosis with Polyvalent Resident Factors of Enterotoxigenic Escherichia Coli

LI Xuewu, ZHANG Gaiping, YAN Yuhe, DENG Ruiguang, YANG Yanyan, WANG Aiping, LI Qingmei   

  1. Institute of Biology and Technique Sciences, Henan Academy of Agricultural Sciences, Zheng zhou 450002, China
  • Received:2000-01-24 Published:2001-06-28

摘要: 应用分子免疫学理论,将定居因子K88,K99,987P,F41与其特异受体结合,封闭肠粘膜上皮细胞的受体,阻断致病菌的定居因子与肠粘膜上皮细胞特异受体的结合,使致病菌无法定居。试验结果显示,其仔猪攻毒保护率为100%,预防试验保护率为100%,可以有效控制仔猪大肠杆菌的发生,为该病的现有预防模式增添了新的内容。

关键词: 仔猪, 致病性大肠杆菌, 定居因子, 预防

Abstract: The resident factors K88,K99,987P and F41 had been combined with the specific receptors of the intestinal mucosa epithelial cells under the molecular immunoreaction,and the specific receptors had been blocked.The receptors blocked by resident factors couldn't attach the resident factors,and prevented the enterotoxigenic E.coli settling down the intestine.The results showed that the piglets infected protection rate was 100%,preventive protection rate was 100%.The experiments proved that the method was effective measures against piglets colibacillosis,and added new content to preventive model at present.

Key words: Piglets, Enterotoxigenic E.coli, Resident factors, Prevention

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引用本文

李学伍, 张改平, 阎玉河, 邓瑞广, 杨艳艳, 王爱萍, 李青梅. ETEC多价定居因子对仔猪大肠杆菌病的预防试验[J]. 华北农学报, 2001, 16(2): 127-131. doi: 10.3321/j.issn:1000-7091.2001.02.025.

LI Xuewu, ZHANG Gaiping, YAN Yuhe, DENG Ruiguang, YANG Yanyan, WANG Aiping, LI Qingmei. Protection Against Piglets Colibacillosis with Polyvalent Resident Factors of Enterotoxigenic Escherichia Coli[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2001, 16(2): 127-131. doi: 10.3321/j.issn:1000-7091.2001.02.025.

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