Abstract: The experimental infection of mammals(such as mice,golden hamsters,guinea-pigs and nude mice)was conducted with MbNPV,HaNPV and PrGV by way of peritoneal and intravenous injection and per os.15-40 days after infection,target insects were reinoculated with the viscera suspension of infected mammals and killed by 13-100%,displaying typical symptoms infected by baculoviruses.Especially,it was important for.positive reaction of the infection via per os,and it indicated that insect baculoviruses could infect mammals.NPV was observed in the ultra thin section of pancreas and spleens which were taken out from infected mammals via peritoneal and intravenous injection under electronmicroscope.

Key words: Insect baculovirus, Mammal, Experimental infection