药食同源植物活性物质对尿酸代谢调控及作用机理研究进展

doi:10.7668/hbnxb.2019261601

摘要/Abstract

摘要： 药食同源植物活性物质具有多环节、多层次、多靶点特点，其发展为降尿酸药物减毒增效及辅助治疗高尿酸食品开发提供新思路。基于嘌呤代谢和尿酸产生途径，概述了高尿酸血症化学合成药物治疗情况，对植源性天然产物提取和高尿酸血症动物模型建造现状进行梳理；从抑制尿素合成、促进尿酸排泄、肾保护作用及减轻炎症等方面分析了典型药食同源植物活性物质调节尿酸代谢途径；最后对药食同源植物活性物质未来发展趋势进行展望。

关键词: 药食同源, 植物活性物质, 尿酸代谢, 黄酮类, 皂苷类, 多糖类, 多酚类

Abstract: Medicinal and food homologous plant active substances have the characteristics of multi-link, multi-level and multi-target, and their development provides a new idea for the development of food which can reduce the toxicity and increase the efficacy of uric acid lowering drugs and play the role of adjuvant therapy.Based on purine metabolism and uric acid production pathways, this paper summarized the treatment of hyperuricemia chemosynthetic drugs, extraction of plant-derived natural products and the construction of animal models of hyperuricemia.In order to inhibit urea synthesis, promote uric acid excretion, protect kidney and reduce inflammation, the regulation of uric acid metabolism by typical plant active substances from food and medicine was analyzed.Finally, the future development trend of medicinal and food homologous plant active substances was prospected.

Key words: Medicine and food homology, Bioactive substances, Flavonoids, Saponins, Polysaccharides, Polyphenols

中图分类号:

R22
R247.1

宋向飞, 雷雅坤, 刘宁, 胡景辉, 孙丽敏, 李树仁. 药食同源植物活性物质对尿酸代谢调控及作用机理研究进展[J]. 华北农学报, 2021, 36(S1): 188-194. doi: 10.7668/hbnxb.2019261601.

SONG Xiangfei, LEI Yakun, LIU Ning, HU Jinghui, SUN Limin, LI Shuren. Research Advances in Regulation and Mechanism of Active Substances from Food and Medicine Resources on Uric Acid Metabolism[J]. ACTA AGRICULTURAE BOREALI-SINICA, 2021, 36(S1): 188-194. doi: 10.7668/hbnxb.2019261601.

http://www.hbnxb.net/CN/Y2021/V36/IS1/188

参考文献

[1] Yang W X,Ma Y,Hou Y L,Wang Y B,You C G.Prevalence of hyperuricemia and its correlation with serum lipids and blood glucose in physical examination population in 2015-2018:a retrospective study[J]. Clinical Laboratory,2019,65(8):1501-1506.doi:10.7754/Clin.Lab.2019.190338.
[2] Luca S V,Macovei I,Bujor A,Miron A,Skalicka-Wozniak K,Aprotosoaie A C,Trifa A.Bioactivity of dietary polyphenols:The role of metabolites[J]. Critical Reviews in Food Science and Nutrition,2020,60(4):626-659.doi:10.1080/10408398.2018.1546669.
[3] Frederic L.Gout furonculosis[J]. Joint Bone Spine,2019,86(1):103.doi:10.1016/j.jbspin.2018.05.002.
[4] Mandal A K,Mount D B.The molecular physiology of uric acid homeostasis[J]. Annual Review of Physiology,2015,77:323-345.doi:10.1146/annurev-physiol-021113-170343.
[5] Stamp L K,Chapman P T,Barclay M,Horne A,Frampton C,Tan P,Drake J,Dalbeth N.Allopurinol dose escalation to achieve serum urate below 6 mg/dL:an open-label extension study[J]. Annals of the Rheumatic Diseases,2017,76(12):2065-2070.doi:10.1136/annrheumdis-2017-211873.
[6] Wallace M C,Roberts R L,Nanavati P,Miner J N,Dalbeth N,Topless R,Mirriman T R,Stamp L K.Association between ABCG2 rs2231142 and poor response to allopurinol:replication and meta-analysis[J]. Rheumatology,2018,57(4):656-660.doi:10.1093/rheumatology/kex467.
[7] White W B,Saog K G,Becker M A,Borer J S,Gorelick P B,Whelton A,Hunt B,Castillo M,Gunawardhana L.Cardiovascular safety of febuxostat or allopurinol in patients with gout[J]. The New England Journal of Medicine,2018,378(13):1200-1210.doi:10.1056/NEJMoa1710895.
[8] Mizukoshi T,Kato S,Ando M,Sobajima H,Ohashi N,Naruse T,Saka Y,Shimizu H,Nagata T,Maruyama S.Renoprotective effects of topiroxostat for hyperuricaemic patients with overt diabetic nephrop-athy study(ETUDE study):a prospective,randomized,multicentre clinical trial[J]. Nephrology,2018,23(11):1023-1030.doi:10.1111/nep.13177.
[9] Yang X J,Huang X,Tian Z,Wang P,Li P H,Zhang J W.Establishment of a novel hyperuricemia animal model using mice and assessment of hyporuricemia action of PNP inhibitor Ulodesine[J]. Chinese Pharmacological Bulletin,2017,33(6):883-886.doi:10.3969/j.issn.1001-1978.2017.06.027.
[10] Hanvivadhanakul P,Akkasilpa S,Deesomchok U.Efficacy of benzbromarone compared to allopurinol in lowering serum uric acid level in hyperuricemic patients[J]. Journal of the Medical Association of Thailand,2002,85(S1):S40-S47.
[11] Shen Z C,Lee C A,Wallach K,Valdez S,Wilson D M,Kerr B,Gillen M.Lesinurad:evaluation of pharmacokinetic and pharmacodynamic interactions with warfarin in healthy volunteers[J]. Clinical Pharmacology in Drug Development,2019,8(5):657-663.doi:10.1002/cpdd.662.
[12] Ishikawa T,Takahashi T,Taniguchi T,Hosoya T.Dotinurad:a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout[J]. Expert Opinion on Pharmacotherapy,2021,22(11):1397-1406.doi:10.1080/14656566.2021.1918102.
[13] Stack AG,Dronamraju N,Parkinson J,Johansson S,Johnsson E,Erlandsson F,Terkeltaub R.Effect of intensive urate lowering with combined verinurad and febuxostat on albuminuria in patients with type 2 diabetes:a randomized trial[J]. American Journal of Kidney Diseases,2021,77(4):481-489.doi:10.1053/j.ajkd.2020.09.009.
[14] Stack A G,Han D,Goldwater R,Johansson S,Dronamraju N,Oscarsson J,Johnsson E,Parkinson J,Erlandsson F.Dapagliflozin added to verinurad plus febuxostat further reduces serum uric acid in hyperuricemia:the QUARTZ study[J]. Journal of Clinical Endocrinology & Metabolism,2021,106(5):E2347-E2356.doi:10.1210/clinem/dgaa748.
[15] Lipsky P E,Calabrese L H,Kavanaugh A,Sundy J S,Wright D,Wolfson,Becker M A.Pegloticase immunogenicity:the relationship between efficacy and anti-body development in patients treated for refractory chronic gout[J]. Arthritis Research Therapy,2014,16(2):104-108.doi:10.1186/ar4497.
[16] Chiu Y C,Hsu T S,Huang C Y,Hsu C H.Molecular elucidation of a urate oxidase from deinococcus radiodurans for hyperuricemia and gout therapy[J]. International Journal of Molecular Sciences,2021,22(11):5611.doi:10.3390/ijms22115611.
[17] Andreis A,Imazio M,Avondo S,Casula M,Paneva E,Piroli F,De Ferrari G M.Adverse events of colchicine for cardiovascular diseases:a comprehensive meta-analysis of 14188 patients from 21 randomized controlled trials[J]. Journal of Cardiovascular Medicine,2021,22(8):637-644.doi:10.2459/JCM.0000000000001157.
[18] Sundy J S,Schumacher H R,Kivitz A,Weinstein S P,Wu R,King-Davis S,Evans R R.Rilonacept for gout flare prevention in patients receiving uric acid-lowering therapy:results of RESURGE,a phase Ⅲ,international safety study[J]. Journal of Rheumatology,2014,41(8):1703-1711.doi:10.3899/jrheum.131226.
[19] Wang M,Zhao J,Zhang N,Chen J H.Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice[J]. Biomedicine & Pharmacotherapy,2016,83:975-988.doi:10.1016/j.biopha.2016.07.025.
[20] Li L Z,Zhou G X,LI J,Li J,Jiang W,Liu B L,Zhou W.Compounds containing trace element copper or zinc exhibit as potent hyperuricemia inhibitors via xanthine oxidase inactivation[J]. Journal of Trace Elements in Medicine and Biology,2018,49:72-78.doi:10.1016/j.jtemb.2018.04.019.
[21] Yousefian M,Shakour N,Hosseinzadeh H,Hayes A W,Hadizadeh F,Karimi G.The natural phenolic compounds as modulators of nadph oxidases in hypertension[J]. Phytomedicine,2019,55:200-213.doi:10.1016/j.phymed.2018.08.002.
[22] 张瑛毓,付劢,范海茹,张丽静,王凤忠.具有降尿酸功效的食品研究进展[J].中国食物与营养,2020,26(1):50-53.doi:10.19870/j.cnki.11-3716/ts.2020.01.013.
Zhang Y Y,Fu M,Fan H R,Zhang L J,Wang F Z.Research progress on food with uric acid lowering effects[J]. Food and Nutrition in China,2020,26(1):50-53.doi:10.19870/j.cnki.11-3716/ts.2020.01.013.
[23] Yuk H J,Lee Y S,Ryu H W,Kim S H,Kim D S.Effects of toona sinensis leaf extract and its chemical constituents on xanthine oxidase activity and serum uric acid levels in potassium oxonate-induced hyperuricemic rats[J]. Molecules,2018,23(12):3254.doi:10.3390/molecules23123254.
[24] 费强,薛稳来,赵耀鑫,赵玲.超声酶解提取高良姜中高良姜素及降尿酸活性研究[J].食品研究与开发,2018,39(20):50-56.doi:10.3969/j.issn.1005-6521.2018.20.010.
Fei Q,Xue W L,Zhao Y X,Zhao L.Study on the extraction of galangin in alpinia officinarum hance by ultrasonic enzymatic and uric acid reduction activities[J]. Food Research and Development,2018,39(20):50-56.
[25] Wang Y J,Zhang G W,Pan J H,Gong D M.Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase[J]. Journal of Agricultural and Food Chemistry,2015,63(2):526-534.doi:10.1021/jf505584m.
[26] Thiel A,Muffler K,Tippkotter N,Suck K,Sohling U,Hruschka S M,Ulber R.A novel integrated downstream processing approach to recover sinapic acid,phytic acid and proteins from rapeseed meal[J]. Journal of Chemical Technology and Biotechnology,2015,90(11):1999-2006.doi:10.1002/jctb.4664.
[27] Muhammad I,Arshad M,Ashfaq U R,Oumeddour D Z,Li J Y,Zhao L,Wang C T,Imam H,Muhammad N,Lian Y H.Antihyperuricemic effect of dietary polyphenol sinapic acid commonly present in various edible food plants[J]. Journal of Food Biochemistry,2020,44(2):e13111.doi:10.1111/jfbc.13111.
[28] Chen G,Tan M L,Li K K,Leung P C.Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice[J]. Journal of Ethnopharmacology,2015,175:14-20.doi:10.1016/j.jep.2015.08.043.
[29] 李思慧,万茵,付桂明,张伦宁,黄婧嫣,陈雪洋,李会晓,朱美金.常见蔬菜醇提物对黄嘌呤氧化酶的抑制作用[J].南昌大学学报(理科版),2015,2(39):163-167.doi:10.13764/j.cnki.ncdl.2015.02.012.
Li S H,Wan Y,Fu G M,Zhang L N,Huang J Y,Chen X Y,Li H X,Zhu M J.Inhibitory effects of ethanol extracts of some common vegetables on xanthine oxidase[J]. Journal of Nanchang University(Natural Science),2015,2(39):163-167.
[30] 祁鑫,王昌禄,李风娟,陈勉华,王玉荣,李专,李亚迪.常见蔬菜提取物对黄嘌呤氧化酶抑制作用的筛选研究[J].现代食品科技,2011,5(27):511-514.doi:10.13982/j.mfst.1673-9078.2011.05.002.
Qi X,Wang C L,Li F J,Chen M H,Wang Y R,Li Z,Li Y D.Inhititory effects of the extracts of some common vegetables on xanthine oxidase[J]. Modern Food Science and Technology,2011,5(27):511-514.
[31] Nile S H,Nile A S,Keum Y S,Sharma K.Utilization of quercetin and quercetin glycosides from onion(Allium cepa L.)solid waste as an antioxidant,urease and xanthine oxidase inhibitors[J]. Food Chemistry,2017,235:119-126.doi:10.1016/j.foodchem.2017.05.043.
[32] Bobulescu I A,Moe O W.Renal transport of uric acid:evolving concepts and uncertainties[J]. Advances in Chronic Kidney Disease,2012,19(6):358-371.doi:10.1053/j.ackd.2012.07.009.
[33] Okada Y,Sim X,Go M J,Wu J Y.Meta-analysis identifies multiple loci associated with kidney function-related trains in east Asian populations[J]. Nature Genetics,2012,44(8):904-909.doi:10.1038/ng.2352.
[34] Mehmood A,Zhao L,Wang C T,Hossen I,Raka R N,Zhang H M.Stevia residue extract increases intestinal uric acid excretion via interactions with intestinal urate transporters in hyperuricemic mice[J]. Food & Function,2019,10(12):7900-7912.doi:10.1039/c9fo02032b.
[35] Sil L Y,Hyung K S,Joo Y H,Seon K D.DKB114,a mixture of chrysanthemum indicum linne flower and cinnamomum cassia(L.)J.presl bark extracts,improves hyperuricemia through Inhibition of xanthine oxidase activity and increasing urine excretion[J]. Nutrients,2018,10(10):1381.doi:10.3390/nu10101381.
[36] Zhu C,Xu Y,Liu Z H,Wan X C,Li D X,Tai L L.The anti-hyperuricemic effect of epigallocatechin-3-gallate(EGCG)on hyperuricemic mice[J]. Biomedicine & Pharmacotherapy,2018,97:168-173.doi:10.1016/j.biopha.2017.10.013.
[37] Zhang R,Zhan S Y,Li S Y,Zhu Z Z,He J R,Lorenzo J M,Barba F J.Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis(Thouin)Koehne in hyperuricemic mice[J]. Food & Function,2018(9):5778-5790.doi:10.1039/c8fo01480a.
[38] Zhang Z C,Su G H,Luo C L,Pang Y L,Wang L,Xing L,Wen J H,Zhang J L.Effects of anthocyanins from purple sweet potato(Ipomoea batatas L.cultivar Eshu No.8)on the serum uric acid level and xanthine oxidase activity in hyperuricemic mice[J]. Food & Function,2015,6(9):3045-3055.doi:10.1039/c5fo00499c.
[39] Chen L,Li M,Wu J L,Li J X,Ma Z C.Effect of lemon water soluble extract on hyperuricemia in a mouse model[J]. Food & Function,2019,10(9):6000-6008.doi:10.1039/c9fo00509a.
[40] Zhu L R,Dong Y F,Na S,Han R,Wei C Y,Chen G L.Saponins extracted from dioscorea collettii rhizomes regulate the expression of urate transporters in chronic hyperuricemia rats[J]. Biomedicine & Pharmacotherapy,2017,93:88-94.doi:10.1016/j.biopha.2017.06.022.
[41] Wang Y,Lin Z J,Zhang B,Nie A Z,Bian M.Cichorium intybus L.promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia[J]. Nutrition & Metabolism,2017,14:38.doi:10.1186/s12986-017-0190-6.
[42] Jiang Y,Lin Y,Hu Y J,Song X J,Pan H H,Zhang H J.Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd.Ameliorates hyperuricemia and acute gouty arthritis in animal model[J]. BMC Complementary and Alternative Medicine,2017,17(2):320.doi:10.1186/s12906-017-1834-9.
[43] Zuo J Y,He H M,Zuo Z Y,Bou C N,Löbenberg R.Erding formula in hyperuricemia treatment:unfolding traditional Chinese herbal compatibility using modern pharmaceutical approaches[J]. Journal of Pharmacy and Pharmacology,2018,70(1):124-132.doi:10.1111/jphp.12840.
[44] Wang M,Zhao J,Zhang N,Chen J H.Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice[J]. Biomedicine & Pharmacotherapy,2016,83:975-988.doi:10.1016/j.biopha.2016.07.025.
[45] 王珂,王瑞坡,李姣,赵頔,王洁琼,冉霞,瞿伟菁.桑叶黄酮对腺嘌呤诱导大鼠高尿酸血症肾损伤的防治作用[J].天然产物研究与开发,2012,24:172-175,202.
Wang K,Wang R P,Li J,Zhao D,Wang J Q,Ran X,Qu W J.The preventive and therapeutic effects of mulberry leaf flavonoids on adenine induced hyperuricemia and kidney injury in rats[J]. Natural Product Research and Development,2012,24:172-175,202.
[46] 朱大帅.薏仁中多酚类化合物降尿酸活性及其作用机制研究[D].广州:华南理工大学,2015.
Zhu D S.In vitro and in vivo studies on phenolic compounds from adlay-derived seed:serum uric acid suppression and the mechanisms[D].Guangzhou:South China University of Technology,2015.
[47] 宓伟,王淇,李小真,张丽,孙璐璐,李朋朋,王芮.山楂原花青素及维生素C联合应用对胰岛素抵抗大鼠肾脏保护作用[J].中草药,2017,21(48):4479-4483.doi:10.7501/j.issn.0253-2670.2017.21.018.
Mi W,Wang Q,Li X Z,Zhang L,Sun L L,Li P P,Wang R.Effects of hawthorn proanthocyanidins and vitamin C on kidney protection in insulin-resistance rats[J]. Chinese Traditional and Herbal Drugs,2017,21(48):4479-4483.
[48] 缪明星,王星,陆琰,王欣.芹菜素对氧嗪酸钾盐致高尿酸血症小鼠的降尿酸及肾保护作用机制研究[J].中国药房,2016,27(34):4794-4797.doi:10.6039/j.issn.1001-0408.2016.34.13.
Miao M X,Wang X,Lu Y,Wang X.Mechanism study on effect of apigenin on reducing uric acid ang renal protection in oteracil potassium-induced hyperuricemia mice[J]. China Pharmacu,2016,27(34):4794-4797.
[49] T L C,Ching C L,Wen L C,Fung W P.Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats[J]. Molecular Nutrition & Food Research,2017,61(10):1601030.doi:10.1002/mnfr.201601030.
[50] Wang M X,Liu Y L,Yang Y,Zhang D M,Kong L D.Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice[J]. European Journal of Pharmacology,2015,747:59-70.doi:10.1016/j.ejphar.2014.11.035.
[51] Jhang J J,Lin J H,Yen G C.Beneficial properties of phytochemicals on NLRP3 inflammasome-mediated gout and complication[J]. Journal of Agricultural and Food Chemistry,2018,66:765-772.doi:10.1021/acs.jafc.7b05113.
[52] Tai L L,Liu Z H,Sun M H,Xie Q J,Cai X Q,Wang Y,Dong X,Xu Y.Anti-hyperuricemic effects of three theaflavins isolated from black tea in hyperuricemic mice[J]. Journal of Functional Foods,2020,66:1-9.doi:10.1016/j.jff.2020.103803.
[53] Gabsik Y,Sang Hyeon Y,Hye Eun L,Han Chang K,Yong Yeon C,Hye Suk L,Joo Young.Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation[J]. Rheumatology,2018,57(4):727-736.doi:10.1093/rheumatology/kex499.
[54] Yang Q B,He Y L,Zhong X W,Xie W G,Zhou J G.Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients[J]. Inflammopharmacology,2019,27:47-56.doi:10.1007/s10787-018-00555-4.
[55] 孙铭,刘春雨,傅文绮,唐营德,刘晓琛,孙佳奇,赵剑.枸杞提取物对慢性高尿酸血症的治疗作用及机制研究[J].中国民族民间医药,2017,24(26):35-37.
Sun M,Liu C Y,Fu W Q,Tang Y D,Liu X S,Sun J Q,Zhao J.Effect and mechanism of Chinese wolfberry extract on serum metabolic substances in mice with chronic hyperuricemia[J]. Chinese Journal of Ethnomedicine and Ethnopharma,2017,24(26):35-37.

选择文件类型/文献管理软件名称

选择包含的内容