摘要： 使用SPF雏鸡进行了鸡传染性囊病二价活疫苗攻击保护效果的观察。14日龄免疫2000TCID50剂量的二价苗或BJ836单价苗，免疫后14d（28日龄）分别用不同剂量（1∶1、1∶10、1∶100）的标准Ⅰ型强毒株CJ801株或标准变异株强毒1084A株进行攻击，攻击后5d剖杀观察。二价苗免疫组能抵抗极高剂量（1∶1）的CJ801株及高剂量（1∶10）的1084A株的攻击，但不能抵抗极高剂量（1∶1）的1084A株攻击。BJ836疫苗免疫组能抵抗高剂量（1∶10）的CJ801珠及低剂量（1∶100）的1084A株的攻击，但不能抵抗极高剂量（1∶1）的CJ801株及高剂量（1∶10）的1084A的攻击。结果表明该二价苗抵抗标准Ⅰ型强毒或变异株强毒的攻击效果均显着优于常规Ⅰ型单价疫苗
关键词:
鸡传染性囊病二价活疫苗,
BJ836中毒力疫苗,
攻击保护效果
Abstract: An observation of efficacy of bivalent live IBD vaccine was conducted using SPF chicks.The chicks were vaccinated at 14 days of age with the bivalent vaccine and a live intermediate strain BJ836 vaccine and challenged 14 days later at different doses(1∶1,1∶10 or 1∶100)of either a standard serotype I virulent IBDV strain CJ801 or a virulent variant of IBDV strain 1084A.The vaccinated group with the bivalent vaccine acquired complete protection against the challenges by the very high dose(1∶1)of strain CJ801 and the high dose(1∶10)of strain 1084A,but had poor protection against the challenges by the very high dose(1∶1)of strain 1084A.The vaccinated group with the BJ836 vaccine acquired complete protection against the challenges by the high dose(1∶10)or strain CJ801 and the low dose(1∶100)of strain 1084A,but had poor protection against the challenges by the very high does(1∶1)of strain CJ801 and the high dose(1∶10)of strain 1084A.This showed that the bivalent vaccine had significantly better protection against the challenges of standard serotype I virulent IBDV strain and virulent variant IBDV strain in comparison with conventional type I IBD vaccines.
Key words:
Bivalent live IBD vaccine,
Live intermediate strain BJ836 vaccine,
Protection
中图分类号:
刘爵, 刘有昌, 姚炜光, 周蛟, 王平. 鸡传染性囊病二价活疫苗攻击保护效果的观察[J]. 华北农学报, 1998, 13(2): 132-136. doi: 10.3321/j.issn:1000-7091.1998.02.025.
Liu Jue, Liu Youchang, Yao Weiguang, Zhou Jiao, Wang Ping. Observation of Efficacy of Bivalent LiveInfectious Bursal Disease VaccineAgainst Virulent IBD Viruses[J]. ACTA AGRICULTURAE BOREALI-SINICA, 1998, 13(2): 132-136. doi: 10.3321/j.issn:1000-7091.1998.02.025.