摘要： 1日龄雏鸡接种鸡马立克氏病二价疫苗(SB-1+HVT)3000PFU,而后18日龄攻以MDBJ-1血毒.定期剖杀三例并观察大体或显微MD组织病变.直至98日龄,在鸡内脏和外周神经等组织中始终可见到网状细胞或淋巴细胞的轻度增生.二价疫苗与HVT冻干苗、SB-1单价苗在相同条件下进行了比较.试验结果表明,眼观病变及组织淋巴细胞增生的出现,病灶范围和病变程度,经二价疫苗免疫的鸡较其他免疫鸡表现轻微.通常二价疫苗仅仅产生长期的轻度非致瘤性组织病理变化.
关键词:
鸡马立克氏病,
二价疫苗
Abstract: Day-old chickens were inoctaated with 3000PFU of a bivalent Marek's disease vaccine(SB-1+HVT) and then challenged with virulent MDBJ-1 at 18 days of age.Three chickens were killed at regular intervals and were exa-mined for macroscopical or microscopical lesions of MD,Up till day 98, mild proliferation of reticulocytes or lymphocytes in the visceral tissues and the external nerves eras still seen.The bivalent vaccine was compared with HVT or SB-1 vaccines under the same conditions,The experimental res-ults showed that the occurrence, extent and degree of macroscopical Icsion and microscopical lymphocytes proliferation in various organs of the chickens immunized with the bivalent vaccine were less than those in the other challenged groups.Usually，the bivalent vaccine only caused mild mieroscopical lesions which were for a long time nontumorous.
Key words:
Marek's disease,
Bivalent vaccrne
陈培红, 周蛟, 姜国华, 徐伟民. 鸡马立克氏病二价疫苗免疫鸡的病理组织学研究[J]. 华北农学报, 1990, 5(1): 111-116. doi: 10.3321/j.issn:1000-7091.1990.01.021.
Chen Peihong, Zhou Jiao, Jiang Guohua, Xu Weimin. A Study on the Pathological Changes of Chickens Immunized with rival ent Marek' s Disease Vacc ine[J]. ACTA AGRICULTURAE BOREALI-SINICA, 1990, 5(1): 111-116. doi: 10.3321/j.issn:1000-7091.1990.01.021.